The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions.

@article{Minocha2003TheUT,
  title={The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions.},
  author={Ranjeet Minocha and Keith Studley and Milton H. Saier},
  journal={Receptors & channels},
  year={2003},
  volume={9 6},
  pages={345-52}
}
We have identified all currently sequenced members of the urea transporter (UT) family (TC #1.A.28). Homologues occur exclusively in vertebrate animals and bacteria but not in other eukaryotic kingdoms or archaea. Sequence, structural, and phylogenetic analyses reveal conserved regions and residues and suggest that a primordial 5 transmembrane helical segment (TMS)-encoding genetic element duplicated to give a 10 TMS-encoding element early during evolutionary history, at about the time when… CONTINUE READING

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