The uptake of cysteine in cultured primary astrocytes and neurons.

  title={The uptake of cysteine in cultured primary astrocytes and neurons.},
  author={Gouri Shanker and Jeffrey Allen and Lysette A Mutkus and Michael Aschner},
  journal={Brain research},
  volume={902 2},
One of the vitally important functions of glutathione (GSH) is to adequately protect cells against toxic chemicals, reactive oxygen metabolites and free radical species. The amino acid, cysteine, is the key rate-limiting substrate for the biosynthesis of GSH, and the maintenance of adequate intracellular GSH levels is dependent upon the extracellular availability and transport of cysteine into cells. In the present study, primary cultures of astrocytes and neurons were employed to characterize… CONTINUE READING

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