Corpus ID: 43510770

The uptake of a substituted acridone by rat mast cells in relationship to histamine release: a possible indicator of exocytosis-induced expansion of the plasma membrane.

@article{Kinsolving1975TheUO,
  title={The uptake of a substituted acridone by rat mast cells in relationship to histamine release: a possible indicator of exocytosis-induced expansion of the plasma membrane.},
  author={C. R. Kinsolving and A. Johnson and N. Moran},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={192 3},
  pages={
          654-69
        }
}
  • C. R. Kinsolving, A. Johnson, N. Moran
  • Published 1975
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • A substituted acridone, 10-(2-dimethylaminopropyl)-9-acridone HCl (M-129), was taken up by isolated rat peritoneal and pleural mast cells in direct relationship to the degree of selective histamine release induced by compound 48/80. Other selective releasing agents, i.e., polymyxin B and anti-rat mast cell serum, also augmented uptake of M-129. Augmented uptake of M-129 was inhibited by measures that inhibited selective histamine release, i.e., cold, brief heating of the mast cells, N… CONTINUE READING
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