The uptake and translocation of latex nanospheres and microspheres after oral administration to rats.

@article{Jani1989TheUA,
  title={The uptake and translocation of latex nanospheres and microspheres after oral administration to rats.},
  author={Prashant Jani and Gavin W Halbert and Johnathan Langridge and Alexander T. Florence},
  journal={The Journal of pharmacy and pharmacology},
  year={1989},
  volume={41 12},
  pages={809-12}
}
Non-ionic and carboxylated fluorescent polystyrene microspheres (100, 500 nm, 1 and 3 microns in diameter), were fed by gavage (2.5% w/v; 1.25 mg kg-1) daily for 10 days to female Sprague Dawley rats. Peyer's patches, villi, liver, lymph nodes and spleen of animals fed the non-ionic microspheres from 100 nm to 1 micron showed unequivocal evidence of uptake and translocation of the particles. Heart, kidney and lung showed no evidence of the presence of microspheres. Carboxylated microspheres… CONTINUE READING

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