The upstream activator CTF/NF1 and RNA polymerase II share a common element involved in transcriptional activation.

@article{Lis1994TheUA,
  title={The upstream activator CTF/NF1 and RNA polymerase II share a common element involved in transcriptional activation.},
  author={John T Lis and Hua Xiao and Jack Greenblatt and James D. Friesen},
  journal={Nucleic acids research},
  year={1994},
  volume={22 11},
  pages={1966-73}
}
The carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II consists of tandem repeats of a heptapeptide with the consensus YSPTSPS. It has been shown that the heptapeptide repeat interacts directly with the general transcription factor TFIID. We report here that the CTD activates transcription when fused to the DNA-binding domain of GAL4. More importantly, we find that the proline-rich transcriptional activation domain of the CCAAT-box-binding factor CTF/NF1 contains a… CONTINUE READING

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