The ups and downs of oral lithium dosing.

  title={The ups and downs of oral lithium dosing.},
  author={Clinton D. Kilts},
  journal={The Journal of clinical psychiatry},
  volume={59 Suppl 6},
  pages={21-6; discussion 27}
As a mood-stabilizing agent, lithium has a long history of documented efficacy as well as risks associated with its use. Relative to other psychiatric medications, lithium exhibits a number of unique pharmacokinetic properties. The use of in vivo nuclear magnetic resonance spectroscopy of the 7Li isotope has immense potential to provide an improved understanding of the pharmacokinetic basis of lithium response and nonresponse. The conventional use of orally administered immediate-release… CONTINUE READING