The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion.

@article{Karumbaiah2012TheUO,
  title={The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion.},
  author={Lohitash Karumbaiah and Sharon E. Norman and Nithish B Rajan and Sanjay Anand and Tarun Saxena and Martha Adiela Lopera Betancur and Radhika Patkar and Ravi V. Bellamkonda},
  journal={Biomaterials},
  year={2012},
  volume={33 26},
  pages={
          5983-96
        }
}
The high mechanical mismatch between stiffness of silicon and metal microelectrodes and soft cortical tissue, induces strain at the neural interface which likely contributes to failure of the neural interface. However, little is known about the molecular outcomes of electrode induced low-magnitude strain (1-5%) on primary astrocytes, microglia and neurons. In this study we simulated brain micromotion at the electrode-brain interface by subjecting astrocytes, microglia and primary cortical… CONTINUE READING

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