The upr-1 gene encodes a catalytic subunit of the DNA polymerase ζ which is involved in damage-induced mutagenesis in Neurospora crassa

@article{Sakai2002TheUG,
  title={The upr-1 gene encodes a catalytic subunit of the DNA polymerase ζ which is involved in damage-induced mutagenesis in Neurospora crassa},
  author={Wataru Sakai and Chizu Ishii and Hirokazu Inoue},
  journal={Molecular Genetics and Genomics},
  year={2002},
  volume={267},
  pages={401-408}
}
The upr-1 mutant was one of the first mutagen-sensitive mutants to be isolated in Neurospora crassa. However, the function of the upr-1 gene has not yet been elucidated, although some genetic and biochemical data have been accumulated. In order to clone the upr-1 gene, we performed a chromosome walk from the mat locus, the closest genetic marker to upr-1 for which a molecular probe was available, towards the centromere, and a chromosomal contig of about 300–400 kb was constructed. Some of these… CONTINUE READING