The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.

@article{Guglielmotto2009TheUO,
  title={The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.},
  author={Michela Guglielmotto and Manuela Aragno and Riccardo Autelli and Luca Giliberto and Erica Novo and Sebastiano Colombatto and Oliviero Danni and Maurizio Parola and Mark A. Smith and George Perry and Elena Tamagno and Massimo Tabaton},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 4},
  pages={1045-56}
}
While it is well established that stroke and cerebral hypoperfusion are both significant risk factors for Alzheimer's disease, the molecular link between ischemia and amyloid precursor protein processing has only been recently established. Specifically, hypoxia significantly increases beta-site APP cleaving enzyme (BACE1) gene transcription through the over-expression of hypoxia inducible factor 1alpha, resulting in increased BACE1 secretase activity and amyloid-beta production. In this study… CONTINUE READING
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