The unusual origin of the polymerase chain reaction.

  title={The unusual origin of the polymerase chain reaction.},
  author={Kary Banks Mullis},
  journal={Scientific American},
  volume={262 4},
          56-61, 64-5
  • K. Mullis
  • Published 1 April 1990
  • Physics, Medicine
  • Scientific American
S ometimes a good idea comes to you when you are not looking for it. Through an improbable combination of coincidences, naivete and lucky mistakes, such a revelation came to me one Friday night in April, 1983, as I gripped the steering wheel of my car and snaked along a moonlit mountain road into northern California's redwood country. That was how I stumbled across a process that could make unlimited numbers of copies of genes, a process now known as the polymerase chain reaction (PCR… Expand
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