The unusual dynamics of parasite actin result from isodesmic polymerization

@inproceedings{Skillman2013TheUD,
  title={The unusual dynamics of parasite actin result from isodesmic polymerization},
  author={Kristen M. Skillman and Christopher I. Ma and Daved H. Fremont and Karthikeyan Diraviyam and John A. Cooper and David Sept and L. David Sibley},
  booktitle={Nature communications},
  year={2013}
}
Previous reports have indicated that parasite actins are short and inherently unstable, despite being required for motility. Here we re-examine the polymerization properties of actin in Toxoplasma gondii, unexpectedly finding that it exhibits isodesmic polymerization in contrast to the conventional nucleation-elongation process of all previously studied actins from both eukaryotes and bacteria. Polymerization kinetics of actin in T. gondii lacks both a lag phase and critical concentration… CONTINUE READING