The unsolved enigmas of leukemia inhibitory factor.

@article{Metcalf2003TheUE,
  title={The unsolved enigmas of leukemia inhibitory factor.},
  author={Donald Metcalf},
  journal={Stem cells},
  year={2003},
  volume={21 1},
  pages={
          5-14
        }
}
Leukemia inhibitory factor (LIF) is a polyfunctional glycoprotein cytokine whose inducible production can occur in many, perhaps all, tissues. LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low-affinity LIF-specific receptor and the gp130 receptor chain also used as the receptor for interleukin-6, oncostatin M, cardiotrophin-1, and ciliary neurotrophic factor. LIF is essential for blastocyst implantation and the normal development of hippocampal and… CONTINUE READING

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