The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function.

@article{Chelvarajan2005TheUO,
  title={The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function.},
  author={R. Lakshman Chelvarajan and Sarah M Collins and Juliana M Van Willigen and Subbarao Bondada},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={77 4},
  pages={503-12}
}
A reduction in macrophage (MPhi) function with aging makes mice less responsive to bacterial capsular polysaccharides, such as those present in the pneumococcal polysaccharide vaccine, a model of thymus independent (TI) antigen (Ag). Using trinitrophenol (TNP)-lipopolysaccharide (LPS) and TNP-Ficoll, two other well-studied TI Ag, we studied the mechanistic basis of reduced MPhi function in the aged. We show that aged mice are profoundly hyporesponsive to these TI Ag. As a result of a… CONTINUE READING

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