The unpredictable caspase-2: what can it do?

  title={The unpredictable caspase-2: what can it do?},
  author={Helin Vakifahmetoglu-Norberg and Boris Zhivotovsky},
  journal={Trends in cell biology},
  volume={20 3},
Caspase-2, the most conserved member of the caspase family, has long been recognized as an important protein in the regulation of apoptosis. However, due to a lack of phenotype in caspase-2 knock-out mice, its precise role has been questioned. Recently, several publications have described new mechanisms regulating caspase-2 activation, including its role within an activating complex named the PIDDosome, linking caspase-2 function to p53. Consistent with this, evidence is accumulating for… CONTINUE READING

From This Paper

Topics from this paper.
48 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…