The unpredictable caspase-2: what can it do?

@article{VakifahmetogluNorberg2010TheUC,
  title={The unpredictable caspase-2: what can it do?},
  author={Helin Vakifahmetoglu-Norberg and Boris Zhivotovsky},
  journal={Trends in cell biology},
  year={2010},
  volume={20 3},
  pages={150-9}
}
Caspase-2, the most conserved member of the caspase family, has long been recognized as an important protein in the regulation of apoptosis. However, due to a lack of phenotype in caspase-2 knock-out mice, its precise role has been questioned. Recently, several publications have described new mechanisms regulating caspase-2 activation, including its role within an activating complex named the PIDDosome, linking caspase-2 function to p53. Consistent with this, evidence is accumulating for… CONTINUE READING

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