The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

@article{Mcelhaney2012TheUN,
  title={The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.},
  author={Janet E. Mcelhaney and Xin Zhou and Helen K B Talbot and Ernst C. Soethout and R. Chris Bleackley and David James Granville and Graham Pawelec},
  journal={Vaccine},
  year={2012},
  volume={30 12},
  pages={
          2060-7
        }
}
Influenza remains the single most important cause of excess disability and mortality during the winter months. In spite of widespread influenza vaccination programs leading to demonstrated cost-savings in the over 65 population, hospitalization and death rates for acute respiratory illnesses continue to rise. As a person ages, increased serum levels of inflammatory cytokines are commonly recorded (TNF-α, IL-1, IL-6). Termed "inflammaging", this has been linked to persistent cytomegalovirus (CMV… CONTINUE READING

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