The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion.

@article{Fritz2011TheUT,
  title={The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion.},
  author={Richard Fritz and Janja Blazevic and Christian Taucher and Karen Pangerl and Franz X Heinz and Karin Stiasny},
  journal={Journal of virology},
  year={2011},
  volume={85 9},
  pages={4377-85}
}
The fusion of enveloped viruses with cellular membranes is mediated by proteins that are anchored in the lipid bilayer of the virus and capable of triggered conformational changes necessary for driving fusion. The flavivirus envelope protein E is the only known viral fusion protein with a double membrane anchor, consisting of two antiparallel transmembrane helices (TM1 and TM2). TM1 functions as a stop-transfer sequence and TM2 as an internal signal sequence for the first nonstructural protein… CONTINUE READING