The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase

@article{Kaitaniemi2009TheUS,
  title={The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase},
  author={Sam Kaitaniemi and Heli Elovaara and Kirsi Gr{\"o}n and Heidi Kidron and Janne Liukkonen and Tiina T Salminen and Marko Salmi and Sirpa Jalkanen and Kati Elima},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={66},
  pages={2743-2757}
}
Semicarbazide-sensitive amine oxidases (SSAOs) catalyze oxidative deamination of primary amines, but the true physiological function of these enzymes is still poorly understood. Here, we have studied the functional and structural characteristics of a human cell-surface SSAO, AOC2, which is homologous to the better characterized family member, AOC3. The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine and benzylamine, the… CONTINUE READING