The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.

@article{Morace2008TheUR,
  title={The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.},
  author={Graziella Morace and Yuri Y Kusov and Georgy Dzagurov and Francesca Beneduce and Verena Gauss-Muller},
  journal={BMB reports},
  year={2008},
  volume={41 9},
  pages={678-83}
}
The initial step during assembly of the hepatitis A virus particle is driven by domain 2A of P1-2A, which is the precursor of the structural proteins. The proteolytic removal of 2A from particulate VP1-2A by an as yet unknown host enzyme presumably terminates viral morphogenesis. Using a genetic approach, we show that a basic amino acid residue at the C-terminus of VP1 is required for efficient particle assembly and that host proteases trypsin and cathepsin L remove 2A from hepatitis A virus… CONTINUE READING
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