The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability

@article{Qiu2010TheUC,
  title={The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability},
  author={Huan Qiu and Marianne Mathaes and Sebastian Nestler and Christopher Bengel and Dieudonn{\'e} Nem and Ute Gödtel-Armbrust and Thomas Lang and Stefan Taudien and Oliver Burk and Leszek Wojnowski},
  journal={Pharmacogenetics and Genomics},
  year={2010},
  volume={20},
  pages={167-178}
}
Objective The individually variable and unpredictable expression of CYP3A4 compromises therapies with 50% of contemporary drugs. Gene variants explain only a fraction of this variability. Methods We investigated the evolution of CYP3A4 transcriptional regulation by nuclear receptors such as the xenobiotics sensors PXR and CAR. Results The combination of a proximal ER6 element with XREM and CLEM represents the original scheme of CYP3A regulation by nuclear receptors in placental mammals. Among… 

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