The unique characteristics of inflammatory responses in mouse brain are acquired during postnatal development.

@article{Lawson1995TheUC,
  title={The unique characteristics of inflammatory responses in mouse brain are acquired during postnatal development.},
  author={Lisa J Lawson and V Hugh Perry},
  journal={The European journal of neuroscience},
  year={1995},
  volume={7 7},
  pages={
          1584-95
        }
}
The kinetics of leukocyte recruitment during acute inflammation in adult mouse brain differ from the stereotyped response occurring in non-CNS tissues; neutrophil recruitment is minimal and monocyte recruitment occurs after a 48 h delay. One aspect of the CNS microenvironment which may contribute to restricted leukocyte recruitment is the highly differentiated nature of resident CNS macrophages, the microglia. Thus we studied the inflammatory response to intracerebral injections of endotoxin in… CONTINUE READING
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