The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.

@article{Neto2015TheUL,
  title={The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.},
  author={Osvaldo P de Melo Neto and Tamara D C da Costa Lima and Camila Cavalcanti Xavier and Larissa M{\'e}lo do Nascimento and Tatiany Patr{\'i}cia Rom{\~a}o and Ludmila Arruda de Assis and Mariana Machado Pereira and Christian Robottom Reis and Barbara Papadopoulou},
  journal={RNA biology},
  year={2015},
  volume={12 11},
  pages={
          1209-21
        }
}
The eukaryotic initiation factor 4E (eIF4E) recognizes the mRNA cap structure and, together with eIF4G and eIF4A, form the eIF4F complex that regulates translation initiation in eukaryotes. In trypanosomatids, 2 eIF4E homologues (EIF4E3 and EIF4E4) have been shown to be part of eIF4F-like complexes with presumed roles in translation initiation. Both proteins possess unique N-terminal extensions, which can be targeted for phosphorylation. Here, we provide novel insights on the Leishmania… CONTINUE READING
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