The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry.

Abstract

6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem… (More)
DOI: 10.1111/j.1749-6632.2008.03679.x

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