The unilateral cobalt wire model of neocortical epilepsy: a method of producing subacute focal seizures in rodents.

In the course of experiments on focal epilepsy in rats, we have recognized that there are no adequate models of subacute focal epilepsy in rodents. We have, therefore, reevaluated a previously described rat model that reliably generates subacute seizures over 2-3 weeks. After implantation of a short length of cobalt wire into the left motor cortex, the… (More)