The unforeseen challenge: from genotype-to-phenotype in cell populations

  title={The unforeseen challenge: from genotype-to-phenotype in cell populations},
  author={Erez Braun},
  journal={Reports on Progress in Physics},
  • E. Braun
  • Published 26 February 2015
  • Biology
  • Reports on Progress in Physics
Biological cells present a paradox, in that they show simultaneous stability and flexibility, allowing them to adapt to new environments and to evolve over time. The emergence of stable cell states depends on genotype-to-phenotype associations, which essentially reflect the organization of gene regulatory modes. The view taken here is that cell-state organization is a dynamical process in which the molecular disorder manifests itself in a macroscopic order. The genome does not determine the… 

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