The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.

@article{Goffin2006TheUP,
  title={The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.},
  author={Laurence Goffin and Sadanand Vodala and Christine Fraser and Joanne Ryan and Mark A Timms and Sarina Meusburger and Bruno Catimel and Edouard C Nice and Pamela A. Silver and C Xiao and David Andrew Jans and M Gething},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 12},
  pages={
          5309-23
        }
}
The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus in Saccharomyces cerevisiae. In this study, we analyzed the capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro. This 18-residue sequence is capable of targeting green fluorescent protein to the nucleus of yeast cells in a process requiring proteins… CONTINUE READING

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