The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast.

@article{Schrder2000TheUP,
  title={The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast.},
  author={Martin Schr{\"o}der and Ji Suk Chang and Randal J Kaufman},
  journal={Genes & development},
  year={2000},
  volume={14 23},
  pages={2962-75}
}
Diploid budding yeast exhibits two developmental programs in response to nitrogen starvation, pseudohyphal growth, and sporulation. Here we show that both programs are repressed by activation of the unfolded protein response (UPR), a stress-signal transduction pathway responsible for induction of endoplasmic reticulum (ER)-resident chaperones when protein folding in the ER is impaired. Pseudohyphal growth was derepressed in ire1Delta/ire1Delta and hac1Delta/hac1Delta strains. Activation of the… CONTINUE READING

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