The unfolded protein response is activated in differentiating epidermal keratinocytes.

@article{Sugiura2009TheUP,
  title={The unfolded protein response is activated in differentiating epidermal keratinocytes.},
  author={Kazumitsu Sugiura and Yoshinao Muro and Kyoko Futamura and Kenji Matsumoto and Noriko Hashimoto and Yuji Nishizawa and Tetsuro Nagasaka and Hirohisa Saito and Yasushi Tomita and Jiro Usukura},
  journal={The Journal of investigative dermatology},
  year={2009},
  volume={129 9},
  pages={2126-35}
}
The unfolded protein response (UPR), which is induced by stress to the endoplasmic reticulum (ER), is involved in the functional alteration of certain cells, such as the differentiation of B cells to plasma cells. The aim of this study is to determine whether the UPR is activated during epidermal keratinocyte (KC) differentiation. Here, we show that the expression of the UPR-induced proteins Bip/GRP78 and HRD1 was increased in cells in the supra-basal layers of normal human epidermis that… CONTINUE READING

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Endoplasmic reticulum stress responses

  • M Schröder
  • Cell Mol Life Sci
  • 2008
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