The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

Abstract

The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins is a common characteristic of neurodegenerative diseases… (More)
DOI: 10.1007/s00401-015-1462-8

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Cite this paper

@inproceedings{Scheper2015TheUP, title={The unfolded protein response in neurodegenerative diseases: a neuropathological perspective}, author={Wiep Scheper and Jeroen J. M. Hoozemans}, booktitle={Acta Neuropathologica}, year={2015} }