The unfolded protein response in multiple sclerosis

  title={The unfolded protein response in multiple sclerosis},
  author={Sarrabeth Stone and Wensheng Lin},
  booktitle={Front. Neurosci.},
The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER. The UPR is comprised of three signaling pathways that promote cytoprotective functions to correct ER stress; however, if ER stress cannot be resolved the UPR results in apoptosis of affected cells. The UPR is an important feature of various human diseases, including multiple sclerosis (MS). Recent studies have shown several… CONTINUE READING
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