The unfolded protein response in lens epithelial cells from galactosemic rat lenses.

@article{Mulhern2006TheUP,
  title={The unfolded protein response in lens epithelial cells from galactosemic rat lenses.},
  author={Michael L. Mulhern and Christian J. Madson and Andrew Danford and Kengo Ikesugi and Peter F. Kador and Toshimichi Shinohara},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={
          3951-9
        }
}
PURPOSE Diabetic complications are associated with hypoglycemia and hyperglycemia. The purpose of this study was to investigate the effect of both glucose deprivation and hyperglycemia on the induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR) that results in apoptosis in in vitro cultured lens epithelial cells (LECs) and in vivo cataract formation in galactose-fed rats. METHODS Lenses from rats fed a standard diet containing 50… CONTINUE READING

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