The unfolded protein response: an intracellular signalling pathway with many surprising features.

@article{Sidrauski1998TheUP,
  title={The unfolded protein response: an intracellular signalling pathway with many surprising features.},
  author={Carmela Sidrauski and Rowan E. Chapman and Peter J. Walter},
  journal={Trends in cell biology},
  year={1998},
  volume={8 6},
  pages={245-9}
}
The unfolded protein response (UPR) is an intracellular signalling pathway--originating in the endoplasmic reticulum (ER) and leading to the cell nucleus--that controls transcription of genes encoding ER-resident proteins. Recent developments in this field show that this pathway utilizes unique regulatory mechanisms, including translational attenuation and a regulated mRNA splicing step catalysed by a bifunctional transmembrane kinase/endoribonuclease and tRNA ligase. This review describes the… CONTINUE READING

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Genes Cells

  • K Mori
  • Nucleic Acids Res
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