The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.

@article{Scheuner2008TheUP,
  title={The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes.},
  author={Donalyn L. Scheuner and Randal J Kaufman},
  journal={Endocrine reviews},
  year={2008},
  volume={29 3},
  pages={317-33}
}
The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized proteins destined for the cell surface or released into the extracellular milieu. The study of protein folding and trafficking within the ER is an extremely active area of research that has provided novel insights into many disease processes. Cells have evolved mechanisms to modulate the capacity and quality of the ER protein-folding machinery to prevent the accumulation of unfolded or misfolded… CONTINUE READING
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