The underlying neurobiology of bipolar disorder.

  title={The underlying neurobiology of bipolar disorder.},
  author={Husseini K. Manji and Jorge A. Quiroz and Jennifer L. Payne and Jaskaran Singh and B{\'a}rbara Pereira Lopes and Jenilee S Viegas and Carlos A. Zarate},
  journal={World psychiatry : official journal of the World Psychiatric Association},
  volume={2 3},
Clinical studies over the past decades have attempted to uncover the biological factors mediating the pathophysiology of bipolar disorder (BD) utilizing a variety of biochemical and neuroendocrine strategies. Indeed, assessments of cerebrospinal fluid chemistry, neuroendocrine responses to pharmacological challenge, and neuroreceptor and transporter binding have demonstrated a number of abnormalities in the amine neurotransmitter systems in this disorder. However, recent studies have also… CONTINUE READING
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