The underling mechanism of bacterial TetR/AcrR family transcriptional repressors.

@article{Deng2013TheUM,
  title={The underling mechanism of bacterial TetR/AcrR family transcriptional repressors.},
  author={Wanyan Deng and Chunmei Li and Jianping Xie},
  journal={Cellular signalling},
  year={2013},
  volume={25 7},
  pages={1608-13}
}
Bacteria transcriptional regulators are classified by their functional and sequence similarities. Member of the TetR/AcrR family is two-domain proteins including an N-terminal HTH DNA-binding motif and a C-terminal ligand recognition domain. The C-terminal ligand recognition domain can recognize the very same compounds as their target transporters transferred. TetRs act as chemical sensors to monitor both the cellular environmental dynamics and their regulated genes underlying many events, such… CONTINUE READING