The uncultured microbial majority.

  title={The uncultured microbial majority.},
  author={Michael S. Rapp{\'e} and Stephen J. Giovannoni},
  journal={Annual review of microbiology},
Since the delineation of 12 bacterial phyla by comparative phylogenetic analyses of 16S ribosomal RNA in 1987 knowledge of microbial diversity has expanded dramatically owing to the sequencing of ribosomal RNA genes cloned from environmental DNA. Currently, only 26 of the approximately 52 identifiable major lineages, or phyla, within the domain Bacteria have cultivated representatives. Evidence from field studies indicates that many of the uncultivated phyla are found in diverse habitats, and… 

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