The uncoupling protein 2 modulates the cytokine balance in innate immunity.

@article{Rousset2006TheUP,
  title={The uncoupling protein 2 modulates the cytokine balance in innate immunity.},
  author={S Brovedani Rousset and Yalin Emre and Olivier F. Join-Lambert and Corinne Hurtaud and Daniel Ricquier and Anne-Marie Cassard-Doulcier},
  journal={Cytokine},
  year={2006},
  volume={35 3-4},
  pages={135-42}
}
The uncoupling protein 2 (UCP2) is located in the inner mitochondrial membrane and downregulates the production of reactive oxygen species (ROS). Recent data suggested a role for UCP2 in the immune response. We analyzed further this hypothesis during acute Listeria monocytogenes infection in mice. Death of infected Ucp2(-/-) mice was delayed in comparison… CONTINUE READING