The unconventional secretion of PepN is independent of a functional autophagy machinery in the filamentous fungus Aspergillus niger.

@article{Burggraaf2016TheUS,
  title={The unconventional secretion of PepN is independent of a functional autophagy machinery in the filamentous fungus Aspergillus niger.},
  author={Anne-Marie Burggraaf and Peter J. Punt and Arthur F. J. Ram},
  journal={FEMS microbiology letters},
  year={2016},
  volume={363 15}
}
During unconventional protein secretion (UPS), proteins do not pass through the classical endoplasmic reticulum (ER)-Golgi-dependent pathway, but are transported to the cell membrane via alternative routes. One type of UPS is dependent on several autophagy-related (Atg) proteins in yeast and mammalian cells, but mechanisms for unconventional secretion are largely unknown for filamentous fungi. In this study, we investigated whether the autophagy machinery is used for UPS in the filamentous… CONTINUE READING
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