The uncontrolled case report: a double-edged sword.

@article{Rickels1988TheUC,
  title={The uncontrolled case report: a double-edged sword.},
  author={Karl E. Rickels and Edward Schweizer and Warren G. Case},
  journal={The Journal of nervous and mental disease},
  year={1988},
  volume={176 1},
  pages={50-2}
}
The advantages and disadvantages of uncontrolled case reports are reviewed using two cases of false-positive reactions to drugs as illustrative examples.