The uncertain glory of APRIL

  title={The uncertain glory of APRIL},
  author={Jan Paul Medema and L Planelles-Carazo and Gijs Hardenberg and Michael Hahne},
  journal={Cell Death and Differentiation},
AbstractThe tumour necrosis factor (TNF) family is intimately connected to the regulation of cellular pathways. A PRoliferation-Inducing Ligand (APRIL) is a rather new member of that family, named for its capacity to stimulate the proliferation of tumour cells in vitro. Subsequent publications also called this ligand TRDL-1 or TALL-2, respectively. APRIL and B-lymphocyte stimulator (BLyS; also termed BAFF, TALL-1, THANK, zTNF4) form a new subfamily of TNF-like ligands that are expressed in… CONTINUE READING


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