The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.

@article{Shreffler1995TheUA,
  title={The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.},
  author={Wayne G. Shreffler and T Magardino and K Shekdar and Eve Wolinsky},
  journal={Genetics},
  year={1995},
  volume={139 3},
  pages={1261-72}
}
Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. Two dominant unc-8 alleles cause motorneuron swelling similar to that of other neuronal types in dominant mutants of the deg-1 gene family, which is homologous to a mammalian gene family encoding amiloride-sensitive sodium channel subunits. As for previously identified deg-1 family members, unc-8 dominant mutations are recessively suppressed by… CONTINUE READING
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