The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression.

@article{Venolia1990TheUG,
  title={The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression.},
  author={L Venolia and Robert H. Waterston},
  journal={Genetics},
  year={1990},
  volume={126 2},
  pages={345-53}
}
We have isolated three novel alleles of the unc-45 locus in C. elegans, that are recessive lethals. Two of these alleles, when homozygous, result in a nearly total loss of muscle contraction with a concomitant arrest of development and a displacement of muscle cells. The third allele is similar, but showed maternal rescue by a wild-type allele. All previously identified unc-45 alleles were temperature sensitive and, although they produced paralysis of adult animals, all were homozygous viable… CONTINUE READING

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