The ulcer sleuths: The search for the cause of peptic ulcers

  title={The ulcer sleuths: The search for the cause of peptic ulcers},
  author={Neville D Yeomans},
  journal={Journal of Gastroenterology and Hepatology},
  • N. Yeomans
  • Published 1 January 2011
  • Medicine
  • Journal of Gastroenterology and Hepatology
The search for the cause or causes of peptic ulcers has been a long one. It was recognised as early as the 19th Century that damage to the stomach or duodenal bulb was likely to result if the resistance of their mucosae to luminal acid was for some reason impaired. An early theory suggested microscopic vascular occlusion leading to local infarction could be the initiating event but evidence was lacking. Excessive acid secretion is seen in some patients but not in many so is implausible as the… 

[Peptic ulcer disease and helicobacter pylori: How we know what we know].

The study of the H. pylori case from the perspective of the history and philosophy of science illustrates how medical knowledge is established incrementally.

A study of changes in stomach wall at sites other than the ulcer in chronic duodenal ulcer patients

Chronic gastritis is caused by presence of Helicobacter pyroli, the most common site for Helicobacters Pyroli is the gastric antrum followed by fundus, and most common pathological abnormality is chronic superficial atrophic gastritis of antrum following by pangastritis.

A Case of Small Bowel Ulcer Associated with Helicobacter pylori

It is found that multiple small bowel ulcerative lesions associated with H. pylori are found in an 11-year-old girl without any systemic disease while performing esophagogastroenteroscopy to the level of the proximal jejunum for differentiating bezoar.

Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans

BackgroundSocietal stress derived from an event that affects the whole society, e. g., a natural disaster, provides a unique, indirect way of determining the relationship between psychological stress

Management of portal hypertensive gastropathy and other bleeding

  • W. Chung
  • Medicine
    Clinical and molecular hepatology
  • 2014
A major cause of cirrhosis related morbidity and mortality is the development of variceal bleeding, a direct consequence of portal hypertension. Less common causes of gastrointestinal bleeding are

The effect of systemic antibiotic prophylaxis for cirrhotic patients with peptic ulcer bleeding after endoscopic interventions

Male gender, cirrhosis Child–Pugh’s class C, and no antibiotic prophylaxis were independent predictors of recurrent bleeding and antibiotics reduced infections and decreased rebleeding.

Update on helicobacter pylori infection

Eradication of H. pylori can lead to a reduction in the occurrence of PUD and prevention of gastric cancer, and in recent years there is increasing concern that the eradication treatment is failing and that there are increasing antimicrobial resistance.

Management of Bleeding Peptic Ulcer Disease

Patients who are deemed too high risk for surgery may benefit from angiographic embolization of the bleeding ulcer that has continued to bleed or has failed other measures.

Comorbidities Affect Risk of Nonvariceal Upper Gastrointestinal Bleeding

Nongastrointestinal comorbidity is an independent risk factor for GIB, and contributes to a greater proportion of patients with bleeding in the population than other recognized risk factors.

Role of Probiotics in Managing of Helicobacter Pylori Infection: A Review.

The analyzed literature suggest that when probiotics are consumed in conjunction with antibiotics, the eradication rate may be improved through modulating the immune response and decreasing the adverse effects of routine drugs leading to gastroprotection.



Bacteria in ulcer pathogenesis.

  • N. Yeomans
  • Medicine
    Bailliere's clinical gastroenterology
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Gastric ulcer with massive hemorrhage following use of phenylbutazone; report of a case.

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  • Medicine
    Journal of the American Medical Association
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Phenylbutazone (Butazolidin) has currently gained general acceptance as an effective agent in the treatment of arthritis and allied rheumatic conditions. That its use is attended with the risk of

Peptic ulcer perforation following administration of phenylbutazone.

It is found that no previous reports of peptic ulcer perforation occurring during or immediately following the administration of phenylbutazone are found and it is believed that the following cases should be recorded.


The general implication of the literature is that no constant or characteristic findings on gastric analysis are associated with peptic ulcer and the inadequacy of the current methods of studying gastric function by means of the ordinary fractional test is drawn attention.

Emotional Antecedents of Perforation of Ulcers of the Stomach and Duodenum

It is concluded that, generally, emotional factors were intimately involved in ulcer perforations, however, the importance of diet, alcohol, activity, and other concurrent disease also was noted.

Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs.

Treatment with high-dose famotidine significantly reduces the cumulative incidence of both gastric and duodenal ulcers in patients with arthritis receiving long-term NSAID therapy.

Helicobacter pylori in peptic ulcer disease.

It is concluded that ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to antisecretory drugs whether on first presentation with the illness or on recurrence.

A study on the correlation of duodenal‐ulcer healing with campylobacter‐like organisms

The conclusion was that CLOS, antral gastritis and duodenal ulcer are closely associated, but that healing of duodental ulcers and improvement of antral Gastritis are unaffected by CLOS.

Aspirin and uncomplicated peptic ulcer.

Evidence will be presented of an association between uncomplicated gastric ulcer in younger women, and the consumption of large quantities of aspirincontaining preparations, usually proprietary


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  • Medicine
    The Review of gastroenterology
  • 1948
Several observations and experiments support the view that the gastric and duodenal mucosa is to a great extent affected by different emotional conditions; the fundamental works by Cannon ( 1909) and Paulou ( 1910) should particularly be mentioned in this context.