The ubiquitylation machinery of the endoplasmic reticulum

@article{Hirsch2009TheUM,
  title={The ubiquitylation machinery of the endoplasmic reticulum},
  author={Christian Hirsch and Robert Gauss and Sabine C. Horn and Oliver Neuber and Thomas M. Sommer},
  journal={Nature},
  year={2009},
  volume={458},
  pages={453-460}
}
As proteins travel through the endoplasmic reticulum (ER), a quality-control system retains newly synthesized polypeptides and supports their maturation. Only properly folded proteins are released to their designated destinations. Proteins that cannot mature are left to accumulate, impairing the function of the ER. To maintain homeostasis, the protein-quality-control system singles out aberrant polypeptides and delivers them to the cytosol, where they are destroyed by the proteasome. The… CONTINUE READING
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