The ubiquitin system: historical perspective.


The discovery of covalent modification of proteins by ubiquitin emerged from a search after an enzyme that will carry out regulated proteolysis of cellular proteins. This was in the mid1970s, when scientists focused mostly on translation of the genetic code into proteins: how proteins are removed had remained a neglected area, regarded as a nonspecific… (More)
DOI: 10.1513/pats.200908-095JS


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