The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival

@article{Peschiaroli2010TheUP,
  title={The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival},
  author={Angelo Peschiaroli and Jeffrey R. Skaar and Michele Pagano and Gerry Melino},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={1384-1393}
}
Ubiquitin-specific proteases (USPs) are a subclass of cysteine proteases that catalyze the removal of ubiquitin (either monomeric or chains) from substrates, thus counteracting the activity of E3 ubiquitin ligases. Although the importance of USPs in a multitude of processes, from hereditary cancer to neurodegeneration, is well established, our knowledge on their mode of regulation, substrate specificity and biological function is quite limited. In this study we identify USP47 as a novel… CONTINUE READING
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