The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.

@article{Moretti2012TheUP,
  title={The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.},
  author={Julien Moretti and Patricia Chastagner and Chih-Chao Liang and Martin A Cohn and Alain Isra{\"e}l and Christel Brou},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 35},
  pages={
          29429-41
        }
}
Notch signaling is critical for development and adult tissue physiology, controlling cell fate in a context-dependent manner. Upon ligand binding, the transmembrane Notch receptor undergoes two ordered proteolytic cleavages releasing Notch intracellular domain, which regulates the transcription of Notch target genes. The strength of Notch signaling is of crucial importance and depends notably on the quantity of Notch receptor at the cell surface. Using an shRNA library screen monitoring Notch… CONTINUE READING
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