The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.

@article{Vos2009TheUP,
  title={The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.},
  author={Robin M Vos and Jennifer Altreuter and Elizabeth A. White and Peter M Howley},
  journal={Journal of virology},
  year={2009},
  volume={83 17},
  pages={8885-92}
}
Proteomic identification of human papillomavirus type 16 (HPV16) E6-interacting proteins revealed several proteins involved in ubiquitin-mediated proteolysis. In addition to the well-characterized E6AP ubiquitin-protein ligase, a second HECT domain protein (HERC2) and a deubiquitylating enzyme (USP15) were identified by tandem affinity purification of HPV16 E6-associated proteins. This study focuses on the functional consequences of the interaction of E6 with USP15. Overexpression of USP15… CONTINUE READING

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