The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation

Abstract

DNA repair is a fundamental cellular function, indispensable for cell survival, especially in conditions of exposure to environmental or pharmacological effectors of DNA damage. The regulation of this function requires a flexible machinery to orchestrate the reversal of harmful DNA lesions by making use of existing proteins as well as inducible gene… (More)
DOI: 10.1111/j.1582-4934.2009.00824.x

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