The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.

@article{Chen2010TheUS,
  title={The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.},
  author={D I Chen and Q Ping Dou},
  journal={Current protein & peptide science},
  year={2010},
  volume={11 6},
  pages={
          459-70
        }
}
Proteasomes are large multicatalytic proteinase complexes located in the cytosol and the nucleus of eukaryotic cells. The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins and therefore plays an essential regulatory role in critical cellular processes including cell cycle progression, proliferation, differentiation, angiogenesis and apoptosis. Besides involving in normal cellular functions and homeostasis, the alteration of proteasomal activity… CONTINUE READING

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