The ubiquitin-proteasome system

  title={The ubiquitin-proteasome system},
  author={D. Nandi and P. Tahiliani and A. Kumar and D. Chandu},
  journal={Journal of Biosciences},
  • D. Nandi, P. Tahiliani, +1 author D. Chandu
  • Published 2007
  • Biology, Medicine
  • Journal of Biosciences
  • The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first ‘tagged’ by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the proteasome. This article recounts the key observations that led to the discovery of ubiquitin-proteasome system (UPS). In addition, different… CONTINUE READING
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